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Adenocarcinoid tumor

MedGen UID:
83124
•Concept ID:
C0334302
•
Neoplastic Process
Synonym: Combined carcinoid and adenocarcinoma
SNOMED CT: Adenocarcinoid tumor (86293007); Mixed carcinoid-adenocarcinoma (51465000); Mixed adenoneuroendocrine carcinoma (51465000); MANEC - mixed adenoneuroendocrine carcinoma (51465000); Composite carcinoid (51465000); Combined carcinoid and adenocarcinoma (51465000)
 
Monarch Initiative: MONDO:0021659

Definition

A malignant epithelial neoplasm composed of a mixture of neuroendocrine cells with morphologic and immunohistochemical characteristics of carcinoid tumor and malignant glandular cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoid tumor

Professional guidelines

PubMed

Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gallbladder: A Systematic Review of Outcomes Following Surgical Management.
Machairas N, Paspala A, Frountzas M, Tsilimigras DI, Moris D, Ntomi V, Tsapralis D, Schizas D
In Vivo 2019 Nov-Dec;33(6):1721-1726. doi: 10.21873/invivo.11662. PMID: 31662496Free PMC Article
Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management.
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015
Management of rectal cancers in relation to treatment guidelines: a population-based study comparing Italian and French patients.
Minicozzi P, Bouvier AM, Faivre J, Sant M; Study working group
Dig Liver Dis 2014 Jul;46(7):645-51. Epub 2014 Apr 18 doi: 10.1016/j.dld.2014.03.009. PMID: 24746280

Recent clinical studies

Etiology

Optimal postoperative surveillance strategies for cancer survivors with gastric neuroendocrine carcinoma based on individual risk: a multicenter real-world cohort study.
Xu BB, He XY, Zhou YB, He QL, Tian YT, Hao HK, Qiu XT, Jiang LX, Zhao G, Li Z, Xu YC, Fu WH, Xue FQ, Li SL, Xu ZK, Zhu ZG, Li Y, Li E, Chen JP, Li HL, Cai LS, Wu D, Li P, Zheng CH, Xie JW, Lu J, Huang CM
Int J Surg 2023 Jun 1;109(6):1668-1676. doi: 10.1097/JS9.0000000000000401. PMID: 37076132Free PMC Article
Mixed adenoneuroendocrine carcinoma of the colon and rectum.
Qiu S, Pellino G, Warren OJ, Mills S, Goldin R, Kontovounisios C, Tekkis PP
Acta Chir Belg 2018 Oct;118(5):273-277. Epub 2018 Jun 17 doi: 10.1080/00015458.2018.1482697. PMID: 29911510
Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management.
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015
Pathology of gastric cancer and its precursor lesions.
Yakirevich E, Resnick MB
Gastroenterol Clin North Am 2013 Jun;42(2):261-84. Epub 2013 Mar 1 doi: 10.1016/j.gtc.2013.01.004. PMID: 23639640
Discordant histology of primary appendiceal adenocarcinoid neoplasms with peritoneal dissemination.
Yan TD, Brun EA, Sugarbaker PH
Ann Surg Oncol 2008 May;15(5):1440-6. Epub 2008 Feb 26 doi: 10.1245/s10434-007-9754-4. PMID: 18299936

Diagnosis

Optimal postoperative surveillance strategies for cancer survivors with gastric neuroendocrine carcinoma based on individual risk: a multicenter real-world cohort study.
Xu BB, He XY, Zhou YB, He QL, Tian YT, Hao HK, Qiu XT, Jiang LX, Zhao G, Li Z, Xu YC, Fu WH, Xue FQ, Li SL, Xu ZK, Zhu ZG, Li Y, Li E, Chen JP, Li HL, Cai LS, Wu D, Li P, Zheng CH, Xie JW, Lu J, Huang CM
Int J Surg 2023 Jun 1;109(6):1668-1676. doi: 10.1097/JS9.0000000000000401. PMID: 37076132Free PMC Article
Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615
Mixed adenoneuroendocrine carcinoma of the colon and rectum.
Qiu S, Pellino G, Warren OJ, Mills S, Goldin R, Kontovounisios C, Tekkis PP
Acta Chir Belg 2018 Oct;118(5):273-277. Epub 2018 Jun 17 doi: 10.1080/00015458.2018.1482697. PMID: 29911510
Mixed adenoneuroendocrine carcinoma: A review of pathologic characteristics.
Brathwaite SA, Smith SM, Wai L, Frankel W, Hays J, Yearsley MM, Abdel-Misih S
Hum Pathol 2018 Mar;73:184-191. Epub 2017 Dec 27 doi: 10.1016/j.humpath.2017.12.009. PMID: 29288693
Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature.
Mandai M, Konishi I, Tsuruta Y, Suginami N, Kusakari T, Iwasaki T, Fujii S
Eur J Obstet Gynecol Reprod Biol 2001 Jul;97(1):90-5. doi: 10.1016/s0301-2115(00)00503-0. PMID: 11435017

Therapy

Optimal postoperative surveillance strategies for cancer survivors with gastric neuroendocrine carcinoma based on individual risk: a multicenter real-world cohort study.
Xu BB, He XY, Zhou YB, He QL, Tian YT, Hao HK, Qiu XT, Jiang LX, Zhao G, Li Z, Xu YC, Fu WH, Xue FQ, Li SL, Xu ZK, Zhu ZG, Li Y, Li E, Chen JP, Li HL, Cai LS, Wu D, Li P, Zheng CH, Xie JW, Lu J, Huang CM
Int J Surg 2023 Jun 1;109(6):1668-1676. doi: 10.1097/JS9.0000000000000401. PMID: 37076132Free PMC Article
In-vivo multispectral video endoscopy towards in-vivo hyperspectral video endoscopy.
Hohmann M, Kanawade R, Klämpfl F, Douplik A, Mudter J, Neurath MF, Albrecht H
J Biophotonics 2017 Apr;10(4):553-564. Epub 2016 Jul 12 doi: 10.1002/jbio.201600021. PMID: 27403639
Does prior percutaneous endoscopic gastrostomy alter post-operative outcome after esophagectomy.
Bhatti AB, Rizvi FH, Waheed A, Raza SH, Syed AA, Khattak S, Aasim Yusuf M
World J Surg 2015 Feb;39(2):441-5. doi: 10.1007/s00268-014-2812-8. PMID: 25270346
Discordant histology of primary appendiceal adenocarcinoid neoplasms with peritoneal dissemination.
Yan TD, Brun EA, Sugarbaker PH
Ann Surg Oncol 2008 May;15(5):1440-6. Epub 2008 Feb 26 doi: 10.1245/s10434-007-9754-4. PMID: 18299936
Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature.
Mandai M, Konishi I, Tsuruta Y, Suginami N, Kusakari T, Iwasaki T, Fujii S
Eur J Obstet Gynecol Reprod Biol 2001 Jul;97(1):90-5. doi: 10.1016/s0301-2115(00)00503-0. PMID: 11435017

Prognosis

Mixed adenoneuroendocrine carcinoma of the colon and rectum.
Qiu S, Pellino G, Warren OJ, Mills S, Goldin R, Kontovounisios C, Tekkis PP
Acta Chir Belg 2018 Oct;118(5):273-277. Epub 2018 Jun 17 doi: 10.1080/00015458.2018.1482697. PMID: 29911510
Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management.
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015
Cytomorphology of neuroendocrine tumours of the gallbladder.
Yadav R, Jain D, Mathur SR, Iyer VK
Cytopathology 2016 Apr;27(2):97-102. Epub 2015 Feb 18 doi: 10.1111/cyt.12239. PMID: 25689921
Discordant histology of primary appendiceal adenocarcinoid neoplasms with peritoneal dissemination.
Yan TD, Brun EA, Sugarbaker PH
Ann Surg Oncol 2008 May;15(5):1440-6. Epub 2008 Feb 26 doi: 10.1245/s10434-007-9754-4. PMID: 18299936
Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature.
Mandai M, Konishi I, Tsuruta Y, Suginami N, Kusakari T, Iwasaki T, Fujii S
Eur J Obstet Gynecol Reprod Biol 2001 Jul;97(1):90-5. doi: 10.1016/s0301-2115(00)00503-0. PMID: 11435017

Clinical prediction guides

Mixed adenoneuroendocrine carcinoma originating from the appendix and colorectum: a comparative analysis of a large population-based database.
Zhao B, Wang J, Ye H, Cheng X, Meng K, Yang T
Tech Coloproctol 2023 Nov;27(11):1017-1024. Epub 2023 Mar 30 doi: 10.1007/s10151-023-02786-2. PMID: 36995458
Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Versus Surgery Without HIPEC for Goblet-Cell Carcinoids and Mixed Adenoneuroendocrine Carcinomas: Propensity Score-Matched Analysis of Centers in the Netherlands and Belgium.
Sluiter NR, van der Bilt JD, Croll DMR, Vriens MR, de Hingh IHJT, Hemmer P, Aalbers AGJ, Bremers AJA, Ceelen W, D'Hoore A, Schoonmade LJ, Coupé V, Verheul H, Kazemier G, Tuynman JB; Dutch Peritoneal Oncology Group
Clin Colorectal Cancer 2020 Sep;19(3):e87-e99. Epub 2020 Jan 30 doi: 10.1016/j.clcc.2020.01.002. PMID: 32651131
Does prior percutaneous endoscopic gastrostomy alter post-operative outcome after esophagectomy.
Bhatti AB, Rizvi FH, Waheed A, Raza SH, Syed AA, Khattak S, Aasim Yusuf M
World J Surg 2015 Feb;39(2):441-5. doi: 10.1007/s00268-014-2812-8. PMID: 25270346
Discordant histology of primary appendiceal adenocarcinoid neoplasms with peritoneal dissemination.
Yan TD, Brun EA, Sugarbaker PH
Ann Surg Oncol 2008 May;15(5):1440-6. Epub 2008 Feb 26 doi: 10.1245/s10434-007-9754-4. PMID: 18299936
Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature.
Mandai M, Konishi I, Tsuruta Y, Suginami N, Kusakari T, Iwasaki T, Fujii S
Eur J Obstet Gynecol Reprod Biol 2001 Jul;97(1):90-5. doi: 10.1016/s0301-2115(00)00503-0. PMID: 11435017

Recent systematic reviews

Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615
MicroRNA-223 in gastrointestinal cancers: A systematic review and diagnostic meta-analysis.
Aalami AH, Abdeahad H, Mesgari M, Sahebkar A
Eur J Clin Invest 2021 Feb;51(2):e13448. Epub 2020 Dec 5 doi: 10.1111/eci.13448. PMID: 33244751
Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Versus Surgery Without HIPEC for Goblet-Cell Carcinoids and Mixed Adenoneuroendocrine Carcinomas: Propensity Score-Matched Analysis of Centers in the Netherlands and Belgium.
Sluiter NR, van der Bilt JD, Croll DMR, Vriens MR, de Hingh IHJT, Hemmer P, Aalbers AGJ, Bremers AJA, Ceelen W, D'Hoore A, Schoonmade LJ, Coupé V, Verheul H, Kazemier G, Tuynman JB; Dutch Peritoneal Oncology Group
Clin Colorectal Cancer 2020 Sep;19(3):e87-e99. Epub 2020 Jan 30 doi: 10.1016/j.clcc.2020.01.002. PMID: 32651131
Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gallbladder: A Systematic Review of Outcomes Following Surgical Management.
Machairas N, Paspala A, Frountzas M, Tsilimigras DI, Moris D, Ntomi V, Tsapralis D, Schizas D
In Vivo 2019 Nov-Dec;33(6):1721-1726. doi: 10.21873/invivo.11662. PMID: 31662496Free PMC Article

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